Structural Snapshots in Reversible Phosphinidene Transfer: Synthetic, Structural, and Reaction Chemistry of a Sn=P Double Bond

The reaction of amido-substituted stannylenes with phospha-Wittig reagents (Me3PPR) results in release of hexamethyldisilazane and tethering of the resulting −CH2PMe2PR fragment to the tin center to give P-donor stabilized stannylenes featuring four-membered Sn,C,P,P heterocycles. Through systematic increases in steric loading, the structures of these systems in the solid state can be tuned, leading to successive P–P bond lengthening and Sn–P contraction and, in the most encumbered case, to complete P-to-Sn transfer of the phosphinidene fragment. The resulting stannaphosphene features a polar Sn=P double bond as determined by structural and computational studies. The reversibility of phosphinidene transfer can be established by solution phase measurements and reactivity studies.

Y oshifuji's synthesis of a stable diphosphene and West's synthesis of tetramesityldisilene, both in 1981, did much to repudiate the so-called "double bond rule" and the implied limit on multiple bonding between heavier main group elements. 1 Since these landmark reports, both homo-and heteronuclear multiple bonds featuring elements from groups 14−16 have attracted enormous interest. 2 With respect to E 14 −E 15 multiple bonds, the initial report of a phosphaalkyne RCP, was followed by the isolation of a range of phosphaalkenes. 3 Sila-imines and heavier imine counterparts of germanium and tin have also been reported. 4 In the realm of E 14 −P multiple bonding, silaphosphenes are well established, and their chemistry has recently been reviewed. 5 However, examples of systems featuring Ge−P or Sn−P multiple bonding are scarce, with stannaphosphenes of type I being advanced in the literature, but with no structural data having been forthcoming (Scheme 1). 6 Inoue and Tan have recently reported the syntheses of germanium and tin compounds (e.g., II) that show short E 14 − P bonds and can be described in terms of a resonance contribution involving an EP double bond. 7 In this context, Inoue and co-workers were able to characterize a zwitterionic stannaphosphene by reacting compound II with B(C 6 F 5 ) 3 . 7a Other notable achievements in heavier E 14 −E 15 multiple bonding include a stibasilene and an arsagermene from Sekiguchi et al., although little reactivity was reported for either compound. 8 Against this limited background of studies in tin phosphorus multiple bonding, we report the isolation of a crystalline stannaphosphene in the solid state. This compound additionally bears an intramolecular pendant phosphine donor and exists in solution as the corresponding four-membered Sn,C,P,P system featuring dative bonding between phosphorus and tin. Steric bulk at both the tin and phosphorus centers is found to be critical in terms of both structure and reactivity. As such, a series of solid-state structures is presented illustrating the stepwise phosphinidene transfer from P to Sn as a function of steric bulk, together with first insights into the reactivity of these compounds. The latter emphasizes the role of reversibility in phosphinidene transfer in the reactivity of the stannaphosphene.
Reactions of the heteroleptic terphenyl-/amido-stannylenes, R TerSn{N(SiMe 3 ) 2 } (Sn1a,b), 9,10 with the phospha-Wittig reagents Me 3 PPR (P1a−c) 11 in the temperature range from room temperature to 80°C lead to the formation of the basestabilized stannylenes (Sn2a−d), each of which features a fourmembered Sn,C,P,P heterocycle in solution and can be isolated in good crystalline yield from aliphatic hydrocarbons (44− 63%) (Scheme 2A). 12 This mode of reactivity of phospha-Wittig reagents (formal methyl C−H activation) is to our knowledge unprecedented, with these reagents commonly acting as phosphinidene transfer reagents via release of PMe 3 . 11,13 In this case, formation of the HN(SiMe 3 ) 2 coproduct is evident from its characteristic 1 H NMR signal (δ H = 0.10 ppm), and the accompanying tin-bound methylene group is revealed by a broad multiplet in the region 0−1 ppm. Retention of the PP double bond from the phospha-Wittig precursor is also reflected in 1 J PP coupling constants for Sn2a− d in the range 300−350 Hz.
Reaction monitoring by 31 P{ 1 H} NMR spectroscopy shows in each case the formation of two new doublet signals with tin satellites, shifted to lower-field compared to the free phospha-Wittig reagents (cf. Figure S15). 11 In a comparative sense, multinuclear NMR data for Sn2a−d (Table S1) imply that the four systems possess near identical structures in solution, with the two 31 P signals being found in the ranges −91.4 to −98.6 and 12.3 to 19.1 ppm (J PP = 312.1−343.2 Hz), and the associated n J SnP couplings being measured at 539.5−656.8 (n = 1) and 231.3−307.3 Hz (n = 2). Crystalline material for each of Sn2a−c was obtained from aliphatic hydrocarbons, with crystallographic study in the cases of Sn2b ( Figure S21) and Sn2c ( Figure 1A) confirming the connectivity implied by solution-phase measurements. 14 In the case of Sn2c, a dative interaction between P2 and Sn1 is suggested by a relatively long bond (2.7727(7) Å), which exceeds the molecular single bond radii of the respective atoms (2.51 Å) 15 and which is aligned approximately perpendicular to the C1−Sn1−C31 stannylene plane. This dative interaction, and the associated four-membered ring, enforces a slightly obtuse Sn1−C31−P1 bond angle of 96.8(1)°. The P1−P2 bond length of 2.1495(10) Å is only slightly elongated compared to phospha-Wittig reagents (cf. Me 3 PP Dipp Ter, 2.0955(7) Å 11 ), thus being characteristic of a double bond. Interestingly, the corresponding data for the slightly less sterically demanding PMes* system Sn2b (notably the Sn1···P2 separation of 2.8345(8) Å and Sn1−C31−P1 angle of 100.2(5)°) imply that the PAr unit becomes more closely linked to the tin center as the Ar group becomes more encumbered. Consistently, the single crystalline material obtained from the reaction of the most sterically demanding stannylene Dipp TerSn{N(SiMe 3 ) 2 } (Sn1b) with Me 3 PP Dipp Ter (P1c) is revealed to consist of the stannaphosphene Dipp Ter-[Me 2 PCH 2 ]SnP Dipp Ter (Sn3; Figure 1, B)), rather than the base-stabilized stannylene Sn2d found in solution.
The Sn1−P1 bond in Sn3 (at 2.3425(4) Å) is the shortest tin−phosphorus bond reported to date and in line with the respective covalent double bond radii (2.32 Å, 15 cf. 2.3450(10) Å in Mes TerSn(C 6 F 4 B(F)(C 6 F 5 ) 2 )P(IDipp) 7a ). Double bond character is further underlined by the sum of angles around the tin center (359.5°) rendering it trigonal planar (cf. Figure 1C). That there is no phosphorus−phosphorus bonding retained in Sn3 is evident by the separation of >5.1 Å, which is markedly wider than both those in Sn2b/Sn2c and the sum of the single bond covalent radii of two phosphorus atoms (2.22 Å 15 ).
Based on these structural data, the series of the structurally characterized compounds Sn2b (PMes*), Sn2c (P Mes Ter), and Sn3 (P Dipp Ter), all bearing the Dipp Ter moiety at tin, can be viewed as offering structural snapshots of phosphinidene transfer as a function of increasing steric bulk. The Sn−P distances contract from 2.8345(8) Å (Sn2b) to 2.7727(7) Å (Sn2c) to 2.3425(4) Å (Sn3), while the associated P−P distances change from 2.1323(12) Å (Sn2b) to 2.1495(10) Å (Sn2c) and >5.1 Å (Sn3) along the series. This seemingly counterintuitive contraction of the Sn−P(Ar) separation as the bulk of Ar increases appears to be related to the torsional alignment of the bulky P-and Sn-bound substituents. In Sn3, the positioning of the two Dipp Ter groups is not constrained by the Sn,C,P,P heterocycle, and the central aryl rings of the two terphenyl ligands can align essentially coplanar to one another (torsion angle = 4.0°), positioned on either side of the SnP double bond (and orthogonal to it). By contrast, in both Sn2b and Sn2c, the analogous conformation is prevented due to the presence of the PMe 2 group adjacent to the PAr unit within the Scheme 2. (A) Synthesis of R TerSnCH 2 P(CH 3 ) 2 PR (Sn2a−c) and Dipp TerSnCH 2 P(CH 3 ) 2  P Dipp Ter/ Dipp TerSn[CH 2 P(CH 3
To obtain insight into the bonding in Sn3 and the thermodynamics of its formation, quantum chemical calcu-lations were performed at the M06-2X/def2-TZVP level. The HOMO and LUMO are best described as SnP π-bonding and π*-antibonding orbitals, respectively ( Figure S70). Natural bonding orbital (NBO) analysis concurs, revealing the presence of both tin−phosphorus σand π-interactions (with occupancies of 1.80e and 1.91e, respectively). The atomic orbital contributions to the π bond have nearly pure p-orbital character with 78% being phosphorus-based. Consistent with this polarized π-bonding description, the Sn−P Wiberg bond index is calculated to be 1.63 and the natural charges are +1.89 (Sn) and −0.42 (P). The formation of the four-membered ring systems Sn2b−Sn2d, bearing Dipp Ter moieties at tin was found to be exothermic and exergonic in all cases, with the most sterically demanding system being the least favorable (ΔG = −7.5 (Sn2b), −10.9 (Sn2c), −7.0 (Sn2d/Sn3) kcal mol −1 ). In the gas phase, the SnP form (Sn3) is calculated to be only slightly higher in energy (+5 kcal mol −1 ) than the corresponding four-membered ring system (Sn2d), in accordance with the phase-dependent structural properties observed experimentally for this system.
While this simple substitution chemistry is common to all four systems, the reactivity toward H 2 and PhCCH reveals behavior that is unique to Sn2d/Sn3. Sn2d/Sn3 reacts with H 2 (>50°C) to generate H 2 P Dipp Ter, with approximately 90% conversion being shown by 31 P and 31 P{ 1 H} NMR spectroscopy over a period of 45 h (Scheme 3 and Figure S56). 10,18,19 In similar fashion, Sn2d/Sn3 is uniquely reactive toward phenylacetylene. A rapid reaction is observed in benzene solution at room temperature, with conversion to two closely related species, each characterized by a pair of mutually coupled doublet signals in the 31 P{ 1 H} NMR spectrum ( Figure  S64). The associated 119 Sn NMR signals are in the same region as the IMe 4 stabilized stannylenes Sn5a−d (δ Sn = −202.0 and −206.5 ppm, respectively). The structure determined crystallographically ( Figure 2) shows that the product ( Dipp TerSn-(CCPh)CH 2 PP(H) Dipp Ter, Sn6) features a tin-bound acetylide moiety and that the pendant phospha-Wittig unit is protonated at P2. Elongation of the P1−P2 bond (2.1997(13) Å, cf. 2.1022(13) Å for Sn5c) is indicative of the reduction in bond order accompanying protonation. Moreover, the Sn1−C39 bond length (2.301(4) Å) is relatively long, being longer even than that involving the carbene donor in Sn5c (2.274(3) Å). This suggests a description as a dative interaction and that Sn6 is best described as an acetylide- substituted stannylene, stabilized by an ylide-type L ligand. We assign the occurrence of two sets of diastereoisomers due to both Sn1 and P2 being stereogenic centers. 20 By contrast, phenylacetylene does not react with the "simple" stannylene/phospha-Wittig adduct Sn2b under comparable conditions, implying that access to the stannaphosphine isomer (as in Sn2d/Sn3) is important in the cleavage of the C−H bond in PhCCH. By analogy with the (intramolecular) activation of C−H bonds by a stanna-imine, 21 we propose that the first step in this chemistry involves cleavage of PhCCH into acetylide and protic components across the polarized SnP double bond in Sn3, with subsequent capture of the [PH Dipp Ter] fragment by the pendant phosphine arm (to generate the product Sn6) further emphasizing the reversible nature of tin−phosphorus interactions in this system.
In conclusion, we show (i) unusual reactivity of mixed metaterphenyl-and amido-substituted stannylenes with phospha-Wittig reagents to give four-membered Sn,C,P,P systems, (ii) that phosphinidene transfer can be achieved through steric overloading, such that the doubly Dipp Ter substituted system exists as the corresponding stannaphosphene in the solid state, (iii) reversibility in phosphinidene transfer for Sn2d/Sn3 in reaction with IMe 4 , and (iv) reactivity studies toward H 2 and HCCPh that imply the importance of access to the SnP bond for enabling small molecule activation.
Synthesis details, NMR spectra, and crystallographic and computational details (PDF) Optimized Cartesian coordinates (XYZ)